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Home   COVID-19 treatment studies for Melatonin  COVID-19 treatment studies for Melatonin  C19 studies: Melatonin  Melatonin   Select treatmentSelect treatmentTreatmentsTreatments
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00.250.50.7511.251.51.752+Alizadeh (SB RCT)73%0.27 [0.07-1.05]no recov.2/149/17Improvement, RR [CI]TreatmentControlTau​2 = 0.00; I​2 = 0.0%Early treatment73%0.27 [0.07-1.05]2/149/1773% improvementRamlall87%0.13 [0.08-0.22]death196 (n)752 (n)Improvement, RR [CI]TreatmentControlDarban (RCT)33%0.67 [0.14-3.17]progression2/103/10CT​1Hosseini48%0.52 [0.36-0.77]recov. time20 (n)20 (n)Farnoosh (DB RCT)81%0.19 [0.01-3.65]ICU0/242/20Sánchez-González54%0.46 [0.28-0.71]death24/22453/224Mousavi (RCT)67%0.33 [0.04-3.09]death1/483/48Tau​2 = 0.35; I​2 = 74.5%Late treatment66%0.34 [0.18-0.65]27/52261/1,07466% improvementJehi58%0.42 [0.26-0.68]cases16/529802/11,143Improvement, RR [CI]TreatmentControlZhou (PSM)21%0.79 [0.65-0.94]casesTau​2 = 0.17; I​2 = 83.5%PrEP40%0.60 [0.33-1.11]16/529802/11,14340% improvementAll studies60%0.40 [0.25-0.65]45/1,065872/12,23460% improvement9 melatonin COVID-19 studiesc19melatonin.com Sep 24, 20211 CT: study uses combined treatmentTau​2 = 0.34; I​2 = 85.4%; Z = 3.68Effect extraction pre-specifiedFavors melatoninFavors control
Database of all melatonin COVID-19 studies. Submit updates/corrections.
 
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Aug 30
Late Mousavi et al., Journal of Medical Virology, doi:10.1002/jmv.27312 (Peer Reviewed) death, ↓66.7%, p=0.62 Melatonin effects on sleep quality and outcomes of COVID-19 patients: An open-label, randomized, controlled trial
Details   RCT 96 hospitalized patients in Iran, 48 treated with melatonin, showing improved sleep quality and SpO2 with treatment. 3mg oral melatonin daily. Authors recommend studies with a higher dose. IRCT20200411047030N1.
Jul 20
Review Ramos et al., Antioxidants, doi:10.3390/antiox10071152 (Review) (Peer Reviewed) review The Coronavirus Disease 2019 (COVID-19): Key Emphasis on Melatonin Safety and Therapeutic Efficacy
Details   Review of melatonin for COVID-19 discussing mechanisms of action and ongoing trials.
Jul 20
Late Sánchez-González (Peer Reviewed) death, ↓54.4%, p<0.0001 What if melatonin could help COVID-19 severe patients?
Details   Retrospective 2,463 hospitalized patients in Spain, 265 treated with melatonin, showing lower mortality with treatment in PSM analysis, however these results are subject to immortal time bias. Authors excluded from the sample patients tha..
Jul 17
Review Camp et al., Journal of Inorganic Biochemistry, doi:10.1016/j.jinorgbio.2021.111546 (Review) (Peer Reviewed) review Melatonin interferes with COVID-19 at several distinct ROS-related steps
Details   Review discussing how melatonin may improve COVID-19 prognosis by acting to reduce oxygen deficiency and hypoxia, vitamin B12 deficiency, NO deficiency, oxidative stress, and sleep disturbance.
Jul 2
Theory Sen, A., OSF Preprints, doi:0.31219/osf.io/xw3np (Preprint) (Theory) theory Deficient synthesis of melatonin in COVID-19 can impair the resistance of coronavirus patients to mucormycosis
Details   Proposal that melatonin deficiency plays a significant role in COVID-19 associated mucormycosis.
Jul 1
Late Davoodian et al., SSRN, doi:10.2139/ssrn.3878090 (Preprint) The Effect of Melatonin as an Adjuvant Therapy on COVID-19: A Randomized Clinical Trial
Details   RCT 81 hospitalized patients in Iran, showing significantly improved oxygen saturation with treatment. Melatonin 3mg, 3x daily for 2 weeks. IRCT20200408046988N1.
Jun 23
Late Farnoosh et al., Archives of Medical Research, doi:10.1016/j.arcmed.2021.06.006 (Peer Reviewed) ICU, ↓81.5%, p=0.20 Efficacy of a Low Dose of Melatonin as an Adjunctive Therapy in Hospitalized Patients with COVID-19: A Randomized, Double-blind Clinical Trial
Details   RCT 44 hospitalized patients in Iran, 24 treated with melatonin, showing faster recovery with treatment. There was no mortality.
Jun 10
Review Cross et al., Endocrine Practice, doi:10.1016/j.eprac.2021.06.001 (Review) (Peer Reviewed) review Melatonin for the Early Treatment of COVID-19: A Narrative Review of Current Evidence and Possible Efficacy
Details   Review of the potential benefits of melatonin for COVID-19.
May 29
Early Alizadeh et al., Iranian Journal of Allergy, Asthma and Immunology (Peer Reviewed) no recov., ↓73.0%, p=0.06 A Pilot Study on Controlling Coronavirus Disease 2019 (COVID-19) Inflammation Using Melatonin Supplement
Details   Small RCT 31 mild/moderate COVID-19 outpatients in Iran, 14 treated with melatonin, showing improved recovery with treatment.
May 17
Late Hosseini et al., European Journal of Pharmacology, doi:10.1016/j.ejphar.2021.174193 (Peer Reviewed) recov. time, ↓47.6%, p=0.001 Evaluation of Th1 and Th2 mediated cellular and humoral immunity in patients with COVID-19 following the use of melatonin as an adjunctive treatment
Details   40 hospitalized patients in Iran, 20 treated with melatonin, showing faster recovery and attenuated inflammatory cytokines with treatment.
Mar 19
Review DiNicolantonio et al., Open Heart, doi:10.1136/openhrt-2020-001568 (Review) (Peer Reviewed) review Melatonin may decrease risk for and aid treatment of COVID-19 and other RNA viral infections
Details   Review of melatonin for COVID-19 and the result of Ramlall et al., suggesting that vitamin D, zinc, and melatonin supplementation may have general utility for the prevention and treatment of RNA virus infections, such as COVID-19 and infl..
Feb 9
PrEP Hancock et al., SSRN, doi:10.2139/ssrn.3779211 (Preprint) Case Cluster of RT-PCR COVID-19 Positive Patients with an Unexpected Benign Clinical Course With Vitamin D, Melatonin, Vitamin C, and Viscum Album
Details   Case series of 24 COVID-19 patients (12 confirmed PCR+) treated with vitamin D, vitamin C, and melatonin, showing positive outcomes with no patient having worse than a mild case, including 7 high risk patients.
Dec 23
2020
Late Brusco et al., Melatonin Research, doi:10.32794/mr11250089 (Peer Reviewed) Efficacy of melatonin in non-intensive care unit patients with COVID-19 pneumonia and sleep dysregulation
Details   Review of melatonin for COVID-19 along with preliminary data suggesting efficacy of melatonin for COVID-19 pneumonia patients.
Dec 15
2020
Late Darban et al., Journal of Cellular & Molecular Anesthesia, doi:10.22037/jcma.v6i2.32182 (Peer Reviewed) progression, ↓33.3%, p=1.00 Efficacy of High Dose Vitamin C, Melatonin and Zinc in Iranian Patients with Acute Respiratory Syndrome due to Coronavirus Infection: A Pilot Randomized Trial
Details   Small RCT in Iran with 20 ICU patients, 10 treated with high-dose vitamin C, melatonin, and zinc, not showing significant differences. IRCT20151228025732N52.
Nov 6
2020
PrEP Zhou et al., PLOS Biology, doi:10.1371/journal.pbio.3000970 (Peer Reviewed) cases, ↓21.1%, p=0.0005 A network medicine approach to investigation and population-based validation of disease manifestations and drug repurposing for COVID-19
Details   PSM observational study with a database of 26,779 patients in the USA, showing significantly lower risk of PCR+ with melatonin usage.
Oct 18
2020
Late Ramlall et al., medRxiv, doi:10.1101/2020.10.15.20213546 (Preprint) death, ↓86.9%, p<0.0001 Melatonin is significantly associated with survival of intubated COVID-19 patients
Details   Retrospective 948 intubated patients, 196 treated with melatonin, showing lower mortality with treatment.
Jun 15
2020
Late Castillo et al., Melatonin Research, doi:10.32794/mr11250063 (Peer Reviewed) Melatonin as adjuvant treatment for coronavirus disease 2019 pneumonia patients requiring hospitalization (MAC-19 PRO): a case series
Details   Report on the use of high-dose melatonin in 10 pneumonia patients, showing clinical stabilization and/or improvement for all patients within 4-5 days. All patients survived, including 3 with moderately severe ARDS and one with mild ARDS. ..
Jun 10
2020
PrEP Jehi et al., Chest, doi:10.1016/j.chest.2020.05.580 (Peer Reviewed) cases, ↓58.0%, p<0.0001 Individualizing Risk Prediction for Positive Coronavirus Disease 2019 Testing
Details   Retrospective 11,672 patients tested for COVID-19, 818 that tested positive, showing significantly lower risk with melatonin use.
May 15
2020
Review Reiter et al., Frontiers in Medicine, doi:10.3389/fmed.2020.00226 (Review) (Peer Reviewed) review Therapeutic Algorithm for Use of Melatonin in Patients With COVID-19
Details   Review of melatonin's action as an antiinflammatory, antioxidant, and antiviral (against other viruses) agent, and proposed therapeutic algorithm for use with COVID-19.
May 4
2020
Review Charaa et al., SSRN, doi:10.2139/ssrn.3601861 (Review) (Preprint) review Prophylactic Treatment Protocol against the Severity of COVID-19 Using Melatonin
Details   Review of the potential benefits of melatonin for COVID-19, and a proposed prophylactic treatment protocol.
Apr 29
2020
Review Shneider et al., International Reviews of Immunology, doi:10.1080/08830185.2020.1756284 (Review) (Peer Reviewed) review Can melatonin reduce the severity of COVID-19 pandemic?
Details   Review of the potential benefits of melatonin for COVID-19.
Mar 23
2020
Review Zhang et al., Life Sciences, doi:10.1016/j.lfs.2020.117583 (Review) (Peer Reviewed) review COVID-19: Melatonin as a potential adjuvant treatment
Details   Review of the potential benefits of melatonin for COVID-19.
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