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0 0.5 1 1.5 2+ Mortality 50% Improvement Relative Risk ICU admission 50% Hospitalization time 9% Sub-intensive hospitaliza.. 39% NIV time 58% High flow oxygen time 8% Sleep time 18% Delirium 33% c19melatonin.com Bologna et al. Melatonin for COVID-19 LATE TREATMENT Favors melatonin Favors control
Bologna, 80 patient melatonin late treatment study: 50% lower mortality [p=0.48], 50% lower ICU admission [p=0.48], 9% shorter hospitalization [p=0.05], and 58% lower need for oxygen therapy [p<0.0001] https://c19p.org/bologna
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Efficacy of Prolonged-Release Melatonin 2 mg (PRM 2 mg) Prescribed for Insomnia in Hospitalized Patients for COVID-19: A Retrospective Observational Study
Bologna et al., Journal of Clinical Medicine, doi:10.3390/jcm10245857
14 Dec 2021    Source   PDF   Share   Tweet
Retrospective 40 hospitalized patients in Italy treated with melatonin and 40 control patients, showing improved sleep, reduced delirium, shorter hospitalization and oxygen times, and reduced ICU admission and mortality (not statistically significant).
risk of death, 50.0% lower, RR 0.50, p = 0.48, treatment 3 of 40 (7.5%), control 6 of 40 (15.0%), NNT 13.
risk of ICU admission, 50.0% lower, RR 0.50, p = 0.48, treatment 3 of 40 (7.5%), control 6 of 40 (15.0%), NNT 13.
hospitalization time, 8.7% lower, relative time 0.91, p = 0.05, treatment mean 31.3 (±6.8) n=40, control mean 34.3 (±6.9) n=40.
relative sub-intensive hospitalization time, 38.8% better, relative time 0.61, p < 0.001, treatment mean 12.3 (±3.0) n=40, control mean 20.1 (±6.1) n=40.
relative NIV time, 58.4% better, relative time 0.42, p < 0.001, treatment mean 5.2 (±3.0) n=40, control mean 12.5 (±4.2) n=40.
relative high flow oxygen time, 7.8% better, relative time 0.92, p = 0.35, treatment mean 7.1 (±2.5) n=40, control mean 7.7 (±3.2) n=40.
relative sleep time, 18.2% better, RR 0.82, p < 0.001, treatment mean 5.5 (±0.8) n=40, control mean 4.5 (±1.2) n=40.
delirium, 33.3% lower, RR 0.67, p < 0.001, treatment mean 2.2 (±1.1) n=40, control mean 3.3 (±1.3) n=40.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Bologna et al., 12/14/2021, retrospective, Italy, Europe, peer-reviewed, 3 authors.
Contact: carolina.bologna@libero.it.
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