Melatonin for the Early Treatment of COVID-19: A Narrative Review of Current Evidence and Possible Efficacy
MS Kristina M Cross, BA Dylan M Landis, BS Laveena Sehgal, DO J Drew Payne
Endocrine Practice, doi:10.1016/j.eprac.2021.06.001
Objective: To discuss the use of melatonin as an early treatment option on the first day of diagnosis for COVID-19. Methods: Medical Subject Headings terms "COVID-19" and "viral diseases" were manually searched on PubMed, and relevant articles were included. Results: The results showed that melatonin acts to reduce reactive oxygen speciesemediated damage, cytokine-induced inflammation, and lymphopenia in viral diseases similar to COVID-19. Conclusion: These conclusions provide evidence for potential benefits in melatonin use for COVID-19 treatment as early as the day of diagnosis.
Author Contributions K.M.C., D.M.L., and L.S. are co-first authors. J.D.P is senior author.
Disclosure The authors have no multiplicity of interest to disclose.
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