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0 0.5 1 1.5 2+ Symptomatic case 7% primary Improvement Relative Risk Case -108% post-hoc primary c19melatonin.com García-García et al. Melatonin for COVID-19 RCT Prophylaxis Favors melatonin Favors control
García-García, 314 patient melatonin prophylaxis RCT: 108% more cases [p=0.26] https://c19p.org/garciagarcia
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Melatonin in the Prophylaxis of SARS-CoV-2 Infection in Healthcare Workers (MeCOVID): A Randomised Clinical Trial
García-García et al., Journal of Clinical Medicine, doi:10.3390/jcm11041139
21 Feb 2022    Source   PDF   Share   Tweet
PrEP RCT healthcare workers in Spain, showing no significant difference in cases with melatonin prophylaxis. Most cases were asymptomatic or paucisymtomatic, there were two symptomatic cases, no moderate/severe cases, and no hospitalization.
The registered primary outcome is symptomatic cases. Authors report on all cases due to the small number of symptomatic cases. They did not include the original primary outcome results in the paper, but have provided the results via email to a contributor.
The dosage in this trial is very low, 2mg daily. Meta regression suggests higher doses are much more effective.
MeCOVID. EudraCT 2020-001530-35. NCT04353128.
risk of symptomatic case, 7.4% lower, RR 0.93, p = 1.00, treatment 1 of 163 (0.6%), control 1 of 151 (0.7%), NNT 2051, primary outcome.
risk of case, 108.4% higher, RR 2.08, p = 0.26, treatment 9 of 163 (5.5%), control 4 of 151 (2.6%), post-hoc primary outcome.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
García-García et al., 2/21/2022, Double Blind Randomized Controlled Trial, placebo-controlled, Spain, Europe, peer-reviewed, 25 authors.
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