40 hospitalized patients in Iran, 20 treated with melatonin, showing faster recovery and attenuated inflammatory cytokines with treatment.
Hosseini et al., 5/17/2021, prospective, Iran, Middle East, peer-reviewed, 9 authors.
recovery time, 47.6% lower, relative time 0.52, p = 0.001, treatment 20, control 20.
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.