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Home   COVID-19 treatment studies for Melatonin  COVID-19 treatment studies for Melatonin  C19 studies: Melatonin  Melatonin   Select treatmentSelect treatmentTreatmentsTreatments
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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality 67% Improvement Relative Risk ICU admission 40% c19melatonin.com/mousavi.html Favors melatonin Favors control
30 August 2021 - Late treatment study
Melatonin effects on sleep quality and outcomes of COVID-19 patients: An open-label, randomized, controlled trial
Mousavi et al., Journal of Medical Virology, doi:10.1002/jmv.27312 (Peer Reviewed)
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RCT 96 hospitalized patients in Iran, 48 treated with melatonin, showing improved sleep quality and SpO2 with treatment. 3mg oral melatonin daily. Authors recommend studies with a higher dose. IRCT20200411047030N1.
risk of death, 66.7% lower, RR 0.33, p = 0.62, treatment 1 of 48 (2.1%), control 3 of 48 (6.2%), NNT 24, day 10.
risk of ICU admission, 40.0% lower, RR 0.60, p = 0.41, treatment 6 of 48 (12.5%), control 10 of 48 (20.8%), NNT 12, day 10.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Mousavi et al., 8/30/2021, Randomized Controlled Trial, Iran, Middle East, peer-reviewed, 7 authors.
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