Melatonin is significantly associated with survival of intubated COVID-19 patients

10/18 Late treatment study

Ramlall et al., medRxiv, doi:10.1101/2020.10.15.20213546 (Preprint)
Melatonin is significantly associated with survival of intubated COVID-19 patients

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Retrospective 948 intubated patients, 196 treated with melatonin, showing lower mortality with treatment.

Ramlall et al., 10/18/2020, retrospective, USA, North America, preprint, 3 authors.

risk of death, 86.9% lower, RR 0.13, p < 0.001, treatment 196, control 752, multivariate model Cox proportional hazards.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

All 9 studies All Outcomes

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