Retrospective 948 intubated patients, 196 treated with melatonin, showing lower mortality with treatment.
Ramlall et al., 10/18/2020, retrospective, USA, North America, preprint, 3 authors.
risk of death, 86.9% lower, RR 0.13, p < 0.001, treatment 196, control 752, multivariate model Cox proportional hazards.
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.