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0 0.5 1 1.5 2+ Mortality 54% Improvement Relative Risk c19melatonin.com Sánchez-González et al. Melatonin LATE TREATMENT Favors melatonin Favors control
Sánchez-González, 448 patient melatonin late treatment study: 54% lower mortality [p=0.0009] https://c19p.org/sanchezgonzalez
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What if melatonin could help COVID-19 severe patients?
Sánchez-González
20 Jul 2021    Source   PDF   Share   Tweet
Retrospective 2,463 hospitalized patients in Spain, 265 treated with melatonin, showing lower mortality with treatment in PSM analysis, however these results are subject to immortal time bias. Authors excluded from the sample patients that died during the first 72 hours of admission without taking melatonin, and patients that started on melatonin in the last 7 days of their admittance, having completed 75% of their stay.
risk of death, 54.4% lower, RR 0.46, p < 0.001, treatment 24 of 224 (10.7%), control 53 of 224 (23.7%), NNT 7.7, odds ratio converted to relative risk, PSM.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
This study is excluded in the after exclusion results of meta analysis: immortal time bias may significantly affect results.
Sánchez-González et al., 7/20/2021, retrospective, Spain, Europe, peer-reviewed, 4 authors.
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