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0 0.5 1 1.5 2+ Mortality 19% Improvement Relative Risk c19melatonin.com Sánchez-Rico et al. Melatonin for COVID-19 LATE Favors melatonin Favors control
Sánchez-Rico, 58,562 patient melatonin late treatment study: 19% lower mortality [p=0.15] https://c19p.org/sanchezrico
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Melatonin does not reduce mortality in adult hospitalized patients with COVID-19: a multicenter retrospective observational study
Sánchez-Rico et al., Journal of Travel Medicine, doi:10.1093/jtm/taab195
5 Feb 2022    Source   PDF   Share   Tweet
Retrospective database analysis in France with 272 patients treated with melatonin, showing 19% lower mortality after adjustments, without statistical significance. Risk was lower for higher dosage (not statistically significant). Age was only in three age ranges and severe COVID was binary, likely leading to substantial residual confounding. Unadjusted differences were extreme with 60% >80 for melatonin compared to 15% for control. Mean daily dose 2.61mg. Title of the paper is incorrect, the most adjusted results show melatonin did reduce mortality (without reaching statistical significance).
risk of death, 19.0% lower, RR 0.81, p = 0.15, treatment 82 of 272 (30.1%), control 6,487 of 58,290 (11.1%), adjusted per study, model b.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Sánchez-Rico et al., 5 Feb 2022, retrospective, France, peer-reviewed, 6 authors, study period 24 January, 2020 - 31 October, 2021.
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