0
0.5
1
1.5
2+
Mortality
4%
Improvement
Relative Risk
Extubation
14%
Ventilation time
27%
Melatonin Alizadeh et al. INTUBATED PATIENTS DB RCT
Is very late treatment with melatonin beneficial for COVID-19?
Double-blind RCT 67 patients in Iran (June - September 2020)
Improved recovery (p=0.19) and shorter ventilation (p=0.091), not sig.
c19early.org
Alizadeh et al., J. Taibah University .., May 2022
Favors melatonin
Favors control