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0 0.5 1 1.5 2+ Case 21% Improvement Relative Risk c19melatonin.com Zhou et al. Melatonin for COVID-19 Prophylaxis Favors melatonin Favors control
Zhou, 26,779 patient melatonin prophylaxis PSM study: 21% fewer cases [p=0.01] https://c19p.org/zhou2
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A network medicine approach to investigation and population-based validation of disease manifestations and drug repurposing for COVID-19
Zhou et al., PLOS Biology, doi:10.1371/journal.pbio.3000970
6 Nov 2020    Source   PDF   Share   Tweet
PSM observational study with a database of 26,779 patients in the USA, showing significantly lower risk of PCR+ with melatonin usage.
risk of case, 21.1% lower, RR 0.79, p = 0.01, treatment 222 of 1,055 (21.0%), control 8,052 of 25,724 (31.3%), NNT 9.7, odds ratio converted to relative risk, PSM.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Zhou et al., 11/6/2020, retrospective, propensity score matching, USA, North America, peer-reviewed, 18 authors.
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