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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Mortality 4% Improvement Relative Risk Extubation 14% Ventilation time 27% c19melatonin.com Alizadeh et al. Melatonin for COVID-19 RCT INTUBATED PATIENTS Favors melatonin Favors control
Alizadeh, 67 patient melatonin ICU RCT: 4% lower mortality [p=0.73], 14% improved recovery [p=0.19], and 27% shorter ventilation [p=0.09] https://c19p.org/alizadeh2
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High dose melatonin as an adjuvant therapy in intubated patients with COVID-19: A randomized clinical trial
Alizadeh et al., Journal of Taibah University Medical Sciences, doi:10.1016/j.jtumed.2022.04.012
13 May 2022    Source   PDF   Share   Tweet
RCT 67 extremely late stage intubated patients in Iran, showing lower CRP with melatonin treatment, but no significant difference in outcomes.
risk of death, 3.8% lower, RR 0.96, p = 0.73, treatment 28 of 33 (84.8%), control 30 of 34 (88.2%), NNT 30.
risk of no extubation, 13.6% lower, RR 0.86, p = 0.19, treatment 26 of 33 (78.8%), control 31 of 34 (91.2%), NNT 8.1.
ventilation time, 27.0% lower, relative time 0.73, p = 0.09, treatment 33, control 34.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Alizadeh et al., 5/13/2022, Double Blind Randomized Controlled Trial, placebo-controlled, Iran, Middle East, peer-reviewed, 11 authors, study period June 2020 - September 2020.
Contact: h-hosami@sina.tums.ac.ir.
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