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Melatonin effect on platelets and coagulation: Implications for a prophylactic indication in COVID-19

Hosseinzadeh et al., Life Sciences, doi:10.1016/j.lfs.2022.120866
Aug 2022  
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Melatonin for COVID-19
10th treatment shown to reduce risk in December 2020
 
*, now known with p = 0.0000002 from 18 studies.
Lower risk for mortality, ventilation, and recovery.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments. c19early.org
Review of the mechanisms and potential benefits of melatonin against coagulopathy induced by SARS-CoV-2 infection.
Reviews covering melatonin for COVID-19 include Alomari, Behl, Camp, Castle, Charaa, Cross, DiNicolantonio, Hosseinzadeh, Langen, Lempesis, Loh, Ramos, Reiter, Reiter (B), Shneider, Tan, Yehia, Zhang.
Hosseinzadeh et al., 6 Aug 2022, peer-reviewed, 7 authors. Contact: sa_mehrzadi@yahoo.com, mehrzadi.s@iums.ac.ir.
This PaperMelatoninAll
Melatonin effect on platelets and coagulation: Implications for a prophylactic indication in COVID-19
Azam Hosseinzadeh, Abolfazl Bagherifard, Fereshteh Koosha, Shiva Amiri, Arman Karimi-Behnagh, Russel J Reiter, Saeed Mehrzadi
Life Sciences, doi:10.1016/j.lfs.2022.120866
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Conflict of interests None declared. References J o u r n a l P r e -p r o o f
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