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0 0.5 1 1.5 2+ Mortality 39% Improvement Relative Risk Ventilation time 43% ICU time 2% c19melatonin.com Karimpour-razkenari et al. Melatonin ICU PATIENTS Favors melatonin Favors control
Karimpour-razkenari, 31 patient melatonin ICU study: 39% lower mortality [p=0.37], 43% shorter ventilation [p=0.13], and 2% shorter ICU admission [p=0.85] https://c19p.org/karimpourrazkenari
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Melatonin as adjunctive therapy in patients admitted to the Covid-19
Karimpour-razkenari et al., Annals of Medicine and Surgery, doi:10.1016/j.amsu.2022.103492
10 Mar 2022    Source   PDF   Share   Tweet
Retrospective 31 ICU patients, 12 treated with melatonin, showing lower mortality with treatment, without statistical significance. Melatonin 15mg daily.
risk of death, 39.0% lower, HR 0.61, p = 0.37, treatment 5 of 12 (41.7%), control 13 of 19 (68.4%), NNT 3.7, Kaplan–Meier.
ventilation time, 42.9% lower, relative time 0.57, p = 0.13, treatment 12, control 19.
ICU time, 1.9% lower, relative time 0.98, p = 0.85, treatment 12, control 19.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Karimpour-razkenari et al., 10 Mar 2022, retrospective, Iran, peer-reviewed, 6 authors, study period 13 March, 2020 - 30 May, 2020.
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